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Correlating Catalyst Characterization Measurements With Productivity in a Pharmaceutical Reaction Frank P. Gortsema, Ralph N. Landau, and Donna G. Blackmond Merck & Co., Inc

Heterogeneous catalytic hydrogenation is a common reaction in many multistep syntheses of pharmaceuticals and fine chemicals. The commercial scale reactions are typically carried out over supported noble metals in liquid-phase batch reactors under mild conditions of temperature and pressure. For this reason, the characteristics required of the catalyst differ somewhat from those of catalysts used in hydrogenation reactions in the petrochemical industry where high-temperature gas-phase conditions predominate. The most important characteristics are outlined below.

Comparison of Static and Dynamic Chemisorption Measurements

In previous issues of Altamira Notes we have discussed the use of pulse chemisorption and temperature-programmed desorption, i.e. dynamic techniques, for catalyst characterization. One question that is often asked is how do results from these techniques compare with results obtained from static volumetric chemisorption methods? This Note compares results for various catalysts obtained by both static and dynamic methods.

Conditions and Parameters for TPD Experiments: Supported Metal Catalysis

Previous Altamira Notes have discussed the use of temperature programmed desorption (TPD) for characterizing the surfaces of metallic catalysts1,2 and acid catalysts3. In this note, we discuss the selection of some critical experimental parameters necessary for conducting a successful TPD experiment on supported metal catalysts.